A multiblock PLS model of cortico-cortical and corticomuscular interactions in Parkinson's disease

► We model concurrent EEG and EMG using multiblock Partial Least Squares (mbPLS). ► Hierarchical structure of mbPLS allows for robust group inference across subjects. ► We analyze EEG/EMG of normal and PD subjects performing a sinusoidal squeezing task. ► Connection strength between EEG electrodes corresponds closely to ongoing EMG. ► Enhanced connectivity to and from occipital region is observed in PD subjects.