5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents

► Tested hypothesis that amygdala is neural locus for 5-HTTLPR × environment interaction ► Additive effects of 5-HTTLPR genotype and recent life events on amygdala reactivity ► Genotype × childhood adversity interaction on neural reactivity in lingual gyrus ► Two forms of environmental adversities interplay with 5-HTTLPR and neural reactivity. ► No support for hypothesized G × E interaction on amygdala reactivity