ReviewRevealing human ocular dominance columns using high-resolution functional magnetic resonance imaging

In this review, I will recall some events at the time when we conducted a high-resolution functional magnetic resonance imaging (fMRI) study mapping ocular dominance columns in humans (Cheng et al., 2001). In particular, I will comment on why and how we had to deal with several key issues in the experimental procedure that we developed in this study, including the adoption of prolonged monocular stimulation, the treatment of large surface veins and the prescription of imaging slice on selected subjects. I will then touch upon several key developments after our work was published and give my thoughts on the challenges that the field of high-resolution fMRI faces.