Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations

► Logan DVR estimate obtained with short time windows has larger bias and variability. ► RE plot approach is more robust as the DVR estimate has less bias and variability. ► DVR estimates obtained by RE plot approach are consistent at voxel and ROI levels. ► RE plot approach provides less noisy parametric DVR images than Logan analysis. ► The findings are not specific to [18F] FDDNP but are also relevant to other radiotracers.