Quantification of serotonin transporter availability with [11C]MADAM - A comparison between the ECAT HRRT and HR systems

► We compared the quantification of [11C]MADAM binding between the HRRT and the HR. ► HRRT provided 31% & 15% higher BPND in cortical & subcortical regions respectively. ► The difference is related to superior resolution in the HRRT. ► PVE-correction improved the agreement (~ 4% difference) in cortical regions. ► In small brainstem regions, no evident difference was observed.