Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain

►Application of intermediate phenotype strategy employing diffusion tensor imaging. ►Risk for bipolar disorder is related to reduced white matter integrity. ►Risk-allele carriers of ANK3 rs10994336 show lower integrity in internal capsule. ►Risk-allele carriers of ANK3 show increased risk-taking and impaired set-shifting. ►White matter integrity in internal capsule is related to risk-taking and set-shifting.