The application of Fourier transform infrared microspectroscopy for the study of diseased central nervous system tissue

► FTIR microspectroscopy reveals biochemical changes in neurodegenerative diseases. ► Discriminate pathology from normal healthy tissue. ► Increase in β-sheet protein secondary structure is an indicator of CNS pathology. ► Rapid, unbiased diagnosis and grading of brain tumour. ► Biochemical evaluation of novel therapeutics.