fMRI of pain processing in the brain: A within-animal comparative study of BOLD vs. CBV and noxious electrical vs. noxious mechanical stimulation in rat

► Nociception during noxious electrical and mechanical stimulations was studied. ► Noxious stimulations induce widespread BOLD and CBV fMRI activations. ► Spatial patterns of fMRI activations are similar during the two stimulations. ► The similarity suggests nociceptive processing is similar during the two stimulations.