Asymmetric bias in user guided segmentations of brain structures

► Expert raters segmented sub-cortical structures on mirrored and original MRI images. ► We compare left-right asymmetry for mirrored and original structures. ► We find significant asymmetric bias for manual and semi-automatic segmentations. ► We perform shape analysis to outline areas with most significant bias. ► We propose potential sources and remedies for such a lateralized asymmetric bias.