Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: Influence of white matter anisotropic conductivity

► Anatomically-realistic head models allow ROI analysis of ECT electric field. ► Bilateral ECT produces the strongest electric field overall and in hippocampus. ► Neglecting white matter anisotropy results in electric field errors up to 39%. ► Computational models could help optimize ECT efficacy and tolerability.