A linear model for estimation of neurotransmitter response profiles from dynamic PET data

► A basis function model estimates neurotransmitter kinetics from PET data. ► Estimated neurotransmitter profiles have temporal precision of ~ 3 min. ► The model can analyze single-scan data and is insensitive to model violations. ► Dopamine responses estimated from rats agree with simultaneous microdialysis. ► Performance is similar to an alternative method, but orders of magnitude faster.