COMT Val108/158Met genotype modulates human sensory gating

► COMT Val158/108Met genotype is not associated with the P50 gating component. ► High prefrontal efficiency is suggested by the COMT Met/Met genotype. ► The prefrontal contribution to N100 gating is more pronounced than in the P50 component. ► Healthy homozygous Met carriers have poorer N100 gating compared to healthy Val carriers. ► High prefrontal processing capacity allows a pronounced afferent input from the auditory cortex. ► High prefrontal processing capacity is associated to poor N100 sensory gating