Brain functional integration decreases during propofol-induced loss of consciousness

► Detection of low frequency fMRI group networks using sICA and clustering. ► Objective, automatic methods to quantify interactions between networks. ► Comparison of resting wakefulness and propofol-induced anesthesia using integration. ► Significant decreases in within- and between-network integration at the brain scale. ► Fronto-parietal segregation of networks during sedation.