کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6034097 | 1188751 | 2011 | 16 صفحه PDF | دانلود رایگان |
Linearly constrained minimum variance beamformers are highly effective for analysis of weakly correlated brain activity, but their performance degrades when correlations become significant. Multiple constrained minimum variance (MCMV) beamformers are insensitive to source correlations but require a priori information about the source locations. Besides the question whether unbiased estimates of source positions and orientations can be obtained remained unanswered. In this work, we derive MCMV-based source localizers that can be applied to both induced and evoked brain activity. They may be regarded as a generalization of scalar minimum-variance beamformers for the case of multiple correlated sources. We show that for arbitrary noise covariance these beamformers provide simultaneous unbiased estimates of multiple source positions and orientations and remain bounded at singular points. We also propose an iterative search algorithm that makes it possible to find sources approximately without a priori assumptions about their locations and orientations. Simulations and analyses of real MEG data demonstrate that presented approach is superior to traditional single-source beamformers in situations where correlations between the sources are significant.
Research highlights⺠Multi-source beamformers for localization of correlated brain activity are introduced. ⺠They provide unbiased estimates of the true source locations and orientations. ⺠Proposed beamformers are not vulnerable to the source cancelation effects. ⺠A source search algorithm allows source localization without a priori assumptions. ⺠Advantages of the new beamformers are demonstrated using simulated and real MEG data.
Journal: NeuroImage - Volume 58, Issue 2, 15 September 2011, Pages 481-496