Identifying gene regulatory networks in schizophrenia

► Brain imaging as a QT phenotype has increased power in identifying risk genes. ► Genes for complex traits do not work in isolation but in gene regulatory networks. ► Schizophrenia associated miRNAs were identified by gene set enrichment analyses. ► Postmortem human and animal transcript levels reveal gene regulatory networks. ► Computational networks identified Glypican1 and FGF17 mouse models of schizophrenia.