Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study

►SERT binding in hypothalamus correlates with tonic heat pain and pain tolerance ►SERT binding in anterior insula correlates with tonic heat pain ►Data suggest serotonergic control of pain in hypothalamus and anterior insula ►These areas may be involved in the modulation or affective processing of pain