Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia

►The fMRI correlates of prosocial sentiments (e.g., guilt, pity and embarrassment) have been previously explored. ►Prosocial sentiments are crucial for adaptive social behaviors and for emotional empathy. ►Fronto-temporal dementia patients show severely impaired social behaviors and reduced empathy. ►Prosocial feeling impairments were selectively associated frontopolar cortex and septal hypometabolism. ►Anger/disgust was associated with dorsolateral prefrontal and amygdala hypometabolism.