Quantitative analysis of hemodynamic and metabolic changes in subcortical vascular dementia using simultaneous near-infrared spectroscopy and fMRI measurements

►Simultaneous NIRS and fMRI recording without hypercapnia. ►Quantification of both hemodynamics and metabolic parameters from SVD patients during a simple motor task. ►In SVD patients, we observed the followings: oxy-hemoglobin, total-hemoglobin, blood oxygenation level-dependent (BOLD) response, cerebral blood flow (CBF), and CMRO2 were decreased significantly in the primary motor and somatosensory cortices. ►Oxygen extraction fraction was increased. ►Flow-metabolism coupling ratio, n, which represents the neurovascular coupling showed a robust reduction.