COMT Val158Met polymorphism, verbalizing of emotion and activation of affective brain systems

► Met allele of COMT Val158Met polymorphism was associated with reduced emotional brain activation. ► This concerned posterior cingulate gyrus and precuneus during a task of valence evaluation. ► The Met allele homozygotes reported difficulties in verbalizing their feelings. ► Met allele may be associated with reduced activation of areas subserving emotional awareness. ► This may contribute to susceptibility for affective disorders.