Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: Comparison of full saturation and steady state methods

► Steady state and full saturation methods to characterise [11C]flumazenil binding. ► A single PET scan is enough for simultaneous estimation of Bmax and KD. ► Successful use of population pharmacokinetic modelling to analyse PET data.