Contrast-to-noise ratios for indices of anisotropy obtained from diffusion MRI: A study with standard clinical b-values at 3Â T

►Evaluated different indices of anisotropy to assess potential for clinical studies. ►Two clinically relevant diffusion MRI acquisition schemes were compared. ►Simulations show significant differences between indices. ►The biological scatter in the brain masks most expected differences. ►Multiple b-values significantly improve the performance of some indices.