Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism

►The APOE-4 allele is associated with medial temporal cortical thinning in healthy people. ►APOE-4 allele carriers compared to non-carriers show greater cortical thinning in the subiculum and entorhinal region over a two2-year interval. ►High resolution MRI can reveal subregional medial temporal cortical thickness changes in healthy subjects.