Altered fronto-cerebellar connectivity in alcohol-naïve youth with a family history of alcoholism

►Contralateral fronto-cerebellar functional connectivity exists in developing youth. ►Youth at high-risk for alcoholism show aberrant fronto-cerebellar connectivity. ►Aberrant fronto-cerebellar functional connectivity relates to structural connectivity. ►Fronto-cerebellar circuitry may be a distinct vulnerability marker for at-risk youth.