Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

► [18F]Y1-973 is readily synthesized with high specific activity. ► [18F]Y1-973 uptake in monkey brain is blocked by pre-dosing an NPY Y1 antagonist. ► In vitro distribution of [18F]Y1-973 is similar in monkey and human brain tissue. ► [18F]Y1-973 is a useful PET tracer for imaging NPY Y1 in monkey. ► [18F]Y1-973 is a promising PET tracer for imaging NPY Y1 in human.