Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510)

► Application of in vivo MRI/S to tauopathy mouse model- rTg4510. ► High resolution 3D MRI can sensitively assess brain atrophy of rTg4510 mice. ► Myo-inositol can be a sensitive biomarker for glial activation. ► The MRI/S findings were verified by histology and immunohistochemistry.