Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers

► We examine the effects of 7 day treatment with two antidepressants (citalopram and reboxetine) on resting-state functional connectivity in healthy volunteers. ► Both citalopram and reboxetine reduce functional connectivity between the amygdala seed region and the prefrontal cortex. ► Antidepressant action may involve normalisation of elevated resting-state functional connectivity between key elements of resting-state networks.