Surface-based TBM boosts power to detect disease effects on the brain: An NÂ =Â 804 ADNI study

►Novel multivariate statistics consisting of multivariate TBM and radial distance. ►A conformal geometry based hippocampal and ventricular surface registration system. ►Hippocampal and ventricular group difference and CSF biomarker correlation on ADNI. ►Comparison with three other statistics and empirical study with reduced sample size. ►A fully automatic brain subcortical morphometry system in the public domain.