کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6035827 | 1188771 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional connectivity to a right hemisphere language center in prematurely born adolescents
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
GLMROIComprehensive Test of Phonological ProcessingWISC-IIISPMPeabody Picture Vocabulary Test-RevisedPPVT-RFSIQCTOPPfcMRIPIQVIQVCIConnectivity - اتصالFunctional connectivity magnetic resonance imaging - تصویربرداری رزونانس مغناطیسی اتصال به عملکردfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیfMRI - تصویرسازی تشدید مغناطیسی کارکردیPremature - زودرسPreterm - زودرسVerbal Comprehension Index - شاخص توزیع کلامیOutcomes - عواقبverbal intelligence quotient - فاکتور اطلاعات کلامیPerformance intelligence quotient - فاکتور هوش عملکردیTERM - مدت، اصطلاحGeneral linear model - مدل خطی کلیFull Scale Intelligence Quotient - مقیاس کامل اطلاعات امتیازBrodmann's area - منطقه برادمنregion of interest - منطقه مورد نظرStatistical Parametric Mapping - نقشه برداری پارامترهای آماریBirth weight - وزن هنگام تولد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Prematurely born children are at increased risk for language deficits at school age and beyond, but the neurobiological basis of these findings remains poorly understood. Thirty-one PT adolescents (600-1250 g birth weight) and 36 T controls were evaluated using an fMRI passive language task and neurodevelopmental assessments including: the Wechsler Intelligence Scale for Children-III (WISC-III), the Peabody Picture Vocabulary Test-Revised (PPVT-R), the Comprehensive Test of Phonological Processing (CTOPP) and the Test of Word Reading Efficiency (TOWRE) at 16 years of age. Neural activity was assessed for language processing and the data were evaluated for connectivity and correlations to cognitive outcomes. PT subjects scored significantly lower on all components of the WISC-III (p < 0.05) compared to term subjects, but there was no significant difference in PPVT-R scores between the groups. Functional connectivity (fcMRI) between Wernicke's area (left BA 22) and the right supramarginal gyrus (BA 40) was increased in preterm subjects relative to term controls (p = 0.03), and the strength of this connection was inversely related to performance on both the PPVT-R (R2 = 0.553, p = 0.002), and the verbal comprehension index (R2 = 0.439, p = 0.019). Preterm adolescents engage a dorsal right hemisphere region for language at age 16 years. Those with the greatest cognitive deficits demonstrate increasing reliance on this alternate pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 51, Issue 4, 15 July 2010, Pages 1445-1452
Journal: NeuroImage - Volume 51, Issue 4, 15 July 2010, Pages 1445-1452
نویسندگان
Eliza H. Myers, Michelle Hampson, Betty Vohr, Cheryl Lacadie, Stephen J. Frost, Kenneth R. Pugh, Karol H. Katz, Karen C. Schneider, Robert W. Makuch, R. Todd Constable, Laura R. Ment,