High-field (9.4Â T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility

► Quantitative magnetic susceptibility mapping provides unique gray and white matter contrast. ► Susceptibility provides a more intrinsic tissue characterization then phase. ► Dysmyelination results in extinction of susceptibility contrast between gray and white matter. ► Myelin is the predominant source of susceptibility contrast in the deep brain white matter. ► Quantitative magnetic susceptibility is a potential sensitive marker for myelination.