Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITC-labeled RBCs in single capillaries

► RBC flow in single capillaries was not stationary. ► RBC redistribution at branches of capillaries without change in diameter. ► RBC flow in capillaries was decreased, occasionally stopped, by K+-induced CSD. ► Sluggish floating movements of RBCs in pertinent capillaries were visualized. ► Slow morphological change of astroglial endfeet was observed after K+ administration.