Accurate epileptogenic focus localization through time-variant functional connectivity analysis of intracranial electroencephalographic signals

► Performance of functional connectivity measures is quantified by simulations. ► Ictal connectivity pattern between IEEG signals reveals epileptogenic zone. ► Revealed epileptogenic zone is concordant with post-surgical findings. ► Ictal connectivity pattern is consistent over 4 seizures and 29 subclinical seizures. ► Connectivity pattern may improve the accuracy of the epileptogenic zone delineation.