Focused ultrasound modulates region-specific brain activity

► Focused ultrasound (FUS) was applied for the modulation of regional brain activity. ► Pulsed FUS was delivered to the rabbit somatomotor and visual areas. ► The brain function was characterized by electroencephalogram and functional MRI. ► The effects were bimodal-neural excitability can be either increased or suppressed. ► FUS provides non-invasive regional modulation of neural tissue excitability.