Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI

► Axonal transport impairment precedes extracellular Aβ and Tau pathologies in 3×Tg-AD mice. ► Quantitative T1 mapping MEMRI with the use of significantly lower MnCl2 dose. ► Quantitative measurement of axonal transport rates in the living mouse brain.