Global-two-stage filtering of clinical PET parametric maps: Application to [11C]-(R)-PK11195

► Global-Two-Stage (GTS) is a robust tool to improve parametric maps in PET ► GTS was compared with the Simplified Reference Tissue Model on a [11C]-(R)-PK11195 data set ► GTS parametric maps were visually improved ► GTS yielded a remarkable increase in sensitivity.