کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6036346 | 1188775 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: A retest study and use of an image-derived input function
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: A retest study and use of an image-derived input function Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: A retest study and use of an image-derived input function](/preview/png/6036346.png)
چکیده انگلیسی
âºBinding of [11C](R)-rolipram to phosphodiesterase 4 can be reliably quantified in human brain using a two-tissue compartment model and a Logan plot. âº[11C](R)-rolipram binding has a moderate test-retest variability of about 15%. âºAn image-derived input function method, using the PET blood pool of carotid arteries, gives almost identical distribution volumes to those obtained with invasive arterial blood sampling. âºThis image input method allows not only the estimation of the whole-blood time activity curve, like all the methods described in the literature up to now, but also the estimation of the parent concentration in plasma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 54, Issue 3, 1 February 2011, Pages 1903-1909
Journal: NeuroImage - Volume 54, Issue 3, 1 February 2011, Pages 1903-1909
نویسندگان
Paolo Zanotti-Fregonara, Sami S. Zoghbi, Jeih-San Liow, Elise Luong, Ronald Boellaard, Robert L. Gladding, Victor W. Pike, Robert B. Innis, Masahiro Fujita,