Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A

►rs1344706, a psychosis risk variant in ZNF804A, impacts on brain connectivity. ►This impact is differentially modulated by the cognitive state of the brain. ►Decreased interhemispheric prefrontal connectivity is independent of cognitive state. ►Increased prefronto-hippocampal connectivity depends on working memory load.