کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6037114 1188783 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV
چکیده انگلیسی
Lower [11C]DASB binding in HIV+ patients compared to HC may reflect serotonergic neuronal loss as a component of generalized HIV-associated neurodegeneration. Higher mean regional BPND values in HIV-D compared to HIV-ND subjects could reflect increased density of 5-HTT, leading to increased clearance of serotonin from the synapse, which could account, in part, for symptoms of depression. The lack of correlation between duration of illness and binding argues against these findings being the result of differential neurodegeneration only. Our findings suggest a possible role for dysregulated serotonergic transmission in HIV-associated depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 49, Issue 3, 1 February 2010, Pages 2588-2595
نویسندگان
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