کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6037114 | 1188783 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV](/preview/png/6037114.png)
چکیده انگلیسی
Lower [11C]DASB binding in HIV+ patients compared to HC may reflect serotonergic neuronal loss as a component of generalized HIV-associated neurodegeneration. Higher mean regional BPND values in HIV-D compared to HIV-ND subjects could reflect increased density of 5-HTT, leading to increased clearance of serotonin from the synapse, which could account, in part, for symptoms of depression. The lack of correlation between duration of illness and binding argues against these findings being the result of differential neurodegeneration only. Our findings suggest a possible role for dysregulated serotonergic transmission in HIV-associated depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 49, Issue 3, 1 February 2010, Pages 2588-2595
Journal: NeuroImage - Volume 49, Issue 3, 1 February 2010, Pages 2588-2595
نویسندگان
Dima A. Hammoud, Christopher J. Endres, Edward Hammond, Ovsev Uzuner, Amanda Brown, Avindra Nath, Adam I. Kaplin, Martin G. Pomper,