کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6038028 | 1188792 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
3D mapping of somatotopic reorganization with small animal functional MRI
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
BOLDCBFCBVpsf - PSFPoint spread function - تابع گسترش نقطهfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیcerebral blood flow - جریان خون مغزیCerebral blood volume - حجم خون مغزیreceptive field - زمینه پذیرشprimary somatosensory cortex - قشر اسموتیسنسوری اولیهCenter-of-mass - مرکز جرمblood oxygen level-dependent - وابسته به سطح اکسیژن خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 3D mapping of somatotopic reorganization with small animal functional MRI 3D mapping of somatotopic reorganization with small animal functional MRI](/preview/png/6038028.png)
چکیده انگلیسی
There are few in vivo noninvasive methods to study neuroplasticity in animal brains. Functional MRI (fMRI) has been developed for animal brain mapping, but few fMRI studies have analyzed functional alteration due to plasticity in animal models. One major limitation is that fMRI maps are characterized by statistical parametric mapping making the apparent boundary dependent on the statistical threshold used. Here, we developed a method to characterize the location of center-of-mass in fMRI maps that is shown not to be sensitive to statistical threshold. Utilizing centers-of-mass as anchor points to fit the spatial distribution of the BOLD response enabled quantitative group analysis of altered boundaries of functional somatosensory maps. This approach was used to study cortical reorganization in the rat primary somatosensory cortex (S1) after sensory deprivation to the barrel cortex by follicle ablation (F.A.). FMRI demonstrated an enlarged nose S1 representation in the 3D somatotopic functional maps. This result clearly demonstrates that fMRI enables the spatial mapping of functional changes that can characterize multiple regions of S1 cortex and still be sensitive to changes due to plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 49, Issue 2, 15 January 2010, Pages 1667-1676
Journal: NeuroImage - Volume 49, Issue 2, 15 January 2010, Pages 1667-1676
نویسندگان
Xin Yu, Shumin Wang, Der-Yow Chen, Stephen Dodd, Artem Goloshevsky, Alan P. Koretsky,