کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6038496 | 1188803 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determining the cortical target of transcranial magnetic stimulation
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Here, a stringent hierarchical sigmoidal model fitting approach is developed that determines the cortical target(s) from TMS mapping based on electric field calculations. Monte-Carlo simulations are used to assess the significance and the goodness-of-fit of the sigmoidal fits, and to obtain confidence regions around the calculated targets. The approach was applied to mapping data on visual suppression (N = 7). In all subjects, we reliably identified two or three neighboring targets commonly contributing to the suppression effect (average distance ± SD: 7.7 ± 2.3 mm). This demonstrates that (i) the assumption of a single CoM is not generally valid and (ii) the combination of TMS mapping with the fitting approach has a cortical resolution of < 1 cm. The estimates for the field strength necessary to achieve 50% of the maximal suppression effect vary noticeably across subjects (mean ± SD: 139 ± 24 V/m), indicating inter-individual differences in the susceptibility to TMS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 47, Issue 4, 1 October 2009, Pages 1319-1330
Journal: NeuroImage - Volume 47, Issue 4, 1 October 2009, Pages 1319-1330
نویسندگان
A. Thielscher, F.A. Wichmann,