کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6038999 | 1188810 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain activation upon selective stimulation of cutaneous C- and Aδ-fibers
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Brain activation upon selective stimulation of cutaneous C- and Aδ-fibers Brain activation upon selective stimulation of cutaneous C- and Aδ-fibers](/preview/png/6038999.png)
چکیده انگلیسی
Thermal and nociceptive cutaneous stimuli activate the brain via two types of nerve fibers, slightly myelinated Aδ-fibers with moderate conduction velocity and unmyelinated C-fibers with slow conduction velocity. Differences in central processing upon selective stimulation of these two fiber types in healthy human subjects still remain poorly understood. By means of event-related functional magnetic resonance imaging the present study investigated brain activation in response to stimulation of Aδ- and C-fibers in healthy subjects. We used the stimulation of tiny skin areas to perform a selective stimulation upon cutaneous C-fibers. Besides similar activation in several brain areas in response to both kinds of stimulation, we observed pronounced brain activation to selective C-fiber stimulation as compared to Aδ-fiber stimulation in the right frontal operculum and anterior insula. Based on a putative function of these structures we suggest that the C-fiber system might be engaged in homeostatic and interoceptive functions in a manner other than the Aδ-fiber system, producing a signal of greater emotional salience.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 41, Issue 4, 15 July 2008, Pages 1372-1381
Journal: NeuroImage - Volume 41, Issue 4, 15 July 2008, Pages 1372-1381
نویسندگان
Thomas Weiss, Thomas Straube, Joachim Boettcher, Holger Hecht, Dorothee Spohn, Wolfgang H.R. Miltner,