کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6039756 | 1188825 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Trial-by-trial variability in local field potential (LFP), tissue partial pressure of oxygen (PO2), cerebral blood flow (CBF), and deoxyhemoglobin-weighted optical imaging of intrinsic signals (OIS) were tested in the rat somatosensory cortex while fixed electrical forepaw stimulation (1.0-ms pulses with amplitude of 1.2 mA at a frequency of 6 Hz) was repeatedly applied. The changes in the cerebral metabolic rate of oxygen (CMRO2) were also evaluated using a hypotension condition established by our group based on the administration of a vasodilator. Under normal conditions, CBF, PO2, and OIS showed positive signal changes (48%, 32%, and 0.42%, respectively) following stimulation. Over multiple trials, the CBF responses were well correlated with the integral of the LFP amplitudes (âLFP) (Rmean = 0.78), whereas a lower correlation was found between PO2 and âLFP (Rmean = 0.60) and between OIS and âLFP (Rmean = 0.54). Under the hypotension condition the LFP responses were preserved, but the CBF responses were suppressed and the PO2 and OIS changes were negative (â 12% and â 0.28%, respectively). In this condition, the trial-by-trial variations in PO2 and OIS were well correlated with the variability in âLFPs (Rmean = â 0.77 and â 0.76, respectively), indicating a single trial coupling between CMRO2 changes and âLFP. These findings show that CBF and CMRO2 signals are more directly correlated with neural activity compared to blood oxygen-sensitive methods such as OIS and BOLD fMRI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 40, Issue 2, 1 April 2008, Pages 442-450
Journal: NeuroImage - Volume 40, Issue 2, 1 April 2008, Pages 442-450
نویسندگان
Kazuto Masamoto, Alberto Vazquez, Ping Wang, Seong-Gi Kim,