Frequency based mutual information measures between clusters of brain regions in functional magnetic resonance imaging

Mutual information tools have been recently applied to quantify the connectivity between brain regions in functional magnetic resonance imaging (fMRI). Here we develop measures of mutual information between clusters of brain regions in the frequency domain. The properties and limitations of the method are exemplified through a single resting state fMRI dataset, and with a comparison involving frontostriatal connections in schizophrenic patients and healthy controls.