کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6048696 | 1191647 | 2015 | 6 صفحه PDF | دانلود رایگان |
- We characterized laser speckle imaging (LSI) in a preclinical burn wound model.
- LSI obtained blood-flow information of superficial-partial and deep-partial thickness burn wounds.
- Blood-flow of superficial-partial and deep-partial burns differed significantly.
- Results suggest the use of LSI to clinically evaluating burn wounds.
A critical need exists for a robust method that enables early discrimination between superficial-partial and deep-partial thickness burn wounds. In this study, we report on the use of laser speckle imaging (LSI), a simple, non-invasive, optical imaging modality, to measure acute blood flow dynamics in a preclinical burn model. We used a heated brass comb to induce burns of varying severity to nine rats and collected raw speckle reflectance images over the course of three hours after burn. We induced a total of 12 superficial-partial and 18 deep-partial thickness burn wounds. At 3 h after burn we observed a 28% and 44% decrease in measured blood flow for superficial-partial and deep-partial thickness burns, respectively, and that these reductions were significantly different (p = 0.00007). This preliminary data suggests the potential role of LSI in the clinical management of burn wounds.
Journal: Burns - Volume 41, Issue 5, August 2015, Pages 1058-1063