Lower Concentrations of B-Vitamin Subgroups in the Serum and Amniotic Fluid Correlate to Cleft Lip and Palate Appearance in the Offspring of A/WySn Mice

A decreased use or uptake of some B-vitamin subgroups (B1, B5, and folic acid) in amniotic fluid and serum (vitamin B1) was correlated to an increased cleft appearance in A/WySn mice. The high thiamin-1 receptor expression in the palatal tissue of mouse fetuses with CL/P may be caused by a decreased availability of vitamin B1.