کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6082375 1205689 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Psychiatric-Medical ComorbidityThe lipid profiles in Japanese patients with schizophrenia treated with antipsychotic agents★
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Psychiatric-Medical ComorbidityThe lipid profiles in Japanese patients with schizophrenia treated with antipsychotic agents★
چکیده انگلیسی

ObjectiveAntipsychotic-treated schizophrenia patients are susceptible to dyslipidemia. However, the results of previous studies of North American and UK populations including various races have been contradictory with regard to which lipid measure was the most affected in patients with schizophrenia taking antipsychotic agents. The aim of this study was to investigate the effect of schizophrenia patients receiving antipsychotic agents on each lipid measure in a Japanese population.MethodsThe samples included 136 control individuals and 157 patients with schizophrenia treated with antipsychotic agents. Age, gender distribution and body mass index (BMI) of the controls were matched with the patients.ResultsThe high-density lipoprotein cholesterol (HDL-cholesterol) levels were significantly lower in patients than in the control subjects (P<.001). However, there were no significant differences in either the low-density lipoprotein cholesterol (LDL-cholesterol) or triglyceride levels between the patient and control groups. We performed a multiple linear regression analysis, and schizophrenia receiving antipsychotics was an independent predictor of decreased HDL-cholesterol. An increased BMI, male gender and cigarette smoking were also major predictors of a decreased HDL-cholesterol level (r2= 0.42, P<.001).ConclusionAt least in Japanese with schizophrenia receiving antipsychotic agents, the HDL-cholesterol levels should be closely monitored in all patients, even those who are not obese or do not smoke, to decrease their risk of cardiovascular disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General Hospital Psychiatry - Volume 34, Issue 5, September–October 2012, Pages 525-528
نویسندگان
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