کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6089254 1208538 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basic nutritional investigationPregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Basic nutritional investigationPregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny
چکیده انگلیسی


- F1 and F2 offspring from pregestational obesity dams were evaluated.
- F2 offspring had hyperinsulinemia, albeit with normal body mass and adequate nutrition.
- F2 offspring had compensatory islet hypertrophy and were not intolerant to glucose.
- F2 offspring presented increased β-cell and α-cell masses.
- Intergenerational pancreatic effects of maternal obesity were observed.

ObjectiveThe aim of this study was to evaluate the effects of maternal obesity on pancreas structure and carbohydrate metabolism in early adult life, focusing on the F1 and F2 generations after F0 maternal pregestational, gestation, and lactation high-fat diet (HF).MethodsC57 BL/6 female mice (F0) were fed standard chow (SC) or an HF diet for 8 wk before mating and during the gestation and lactation periods to provide the F1 generation (F1-SC and F1-HF). At 3 mo old, F1 females were mated to produce the F2 generation (F2-SC and F2-HF). The male offspring from all groups were evaluated at 3 mo old.ResultsF0-HF and F1-HF dams were overweight before gestation and had a higher body mass gain and energy intake during gestation, although only F0-HF dams presented pregestational hyperglycemia. The F1-HF offspring had higher body mass, energy intake, fasting glucose levels, and were glucose intolerant compared with F1-SC offspring. These parameters were not significantly altered in F2-HF offspring. Both F1-HF and F2-HF offspring showed hyperinsulinemia, hyperleptinemia, decreased adiponectin levels, increased pancreatic mass, and islet volume density with elevated α- and β-cell mass, hypertrophied islet characterized by an altered distribution of α- and β-cells and weak pancreatic-duodenal homeobox (Pdx)1 immunoreactivity.ConclusionsMaternal HF diet consumed during the preconception period and throughout the gestation and lactation periods in mice promotes metabolism and pancreatic programming in F1 and F2 male offspring, implying intergenerational effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 31, Issue 2, February 2015, Pages 380-387
نویسندگان
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