کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6089690 1208549 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applied nutritional investigationRandomized clinical trial: Effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Applied nutritional investigationRandomized clinical trial: Effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome
چکیده انگلیسی

ObjectivesIrritable bowel syndrome (IBS) is a common diagnosis in gastroenterology. Its etiology is unknown and therapeutic options limited. Trials suggest probiotics may be beneficial. The aim of this study was to assess the symptomatic efficacy of Lactobacillus plantarum 299 v (L. plantarum 299 v) for the relief of abdominal pain in patients with IBS fulfilling Rome II criteria.MethodsThis study was conducted in a referral hospital. Trial participants were randomized to receive either two capsules of L. plantarum 299 v at a dosage of 5 × 109 cfu per capsule or placebo daily for 8 wk. Severity of abdominal pain was assessed using a visual analog scale at each visit and a quality-of-life IBS (QoL-IBS) questionnaire was also completed.ResultsThere was no significant difference in abdominal pain relief between the study and placebo groups (P = 0.800). There was also no difference in QoL- IBS scores between the groups (P = 0.687). Both groups had a significant improvement in abdominal pain scores over the study period, from an average of 251.55 to 197.90 (P < 0.0001) indicating a large placebo effect.ConclusionAn 8-wk treatment with L. plantarum 299 v did not provide symptomatic relief, particularly of abdominal pain and bloating, in patients fulfilling the Rome II criteria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 30, Issue 10, October 2014, Pages 1151-1157
نویسندگان
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