کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6089867 1208559 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applied nutritional investigationStimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism
ترجمه فارسی عنوان
تحقیقات تغذیه ای کاربردی تحریک کتونمی خفیف و پایدار توسط تریاسیل گلیسیرین های متوسط ​​در انسان سالم: سهم بالقوه متابولیسم انرژی مغز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

ObjectiveIn humans consuming a normal diet, we investigated 1) the capacity of a medium-chain triacylglycerol (MCT) supplement to stimulate and sustain ketonemia, 2) 13C-β-hydroxybutyrate and 13C-trioctanoate metabolism, and 3) the theoretical contribution of the degree of ketonemia achieved to brain energy metabolism.MethodsEight healthy adults (26 ± 1 y old) were given an MCT supplement for 4 wk (4 times/d; total of 20 g/d for 1 wk followed by 30 g/d for 3 wk). Ketones, glucose, triacylglycerols, cholesterol, free fatty acids, and insulin were measured over 8 h during two separate metabolic study days before and after MCT supplementation. Using isotope ratio mass spectroscopy, 13C-D-β-hydroxybutyrate and 13C-trioctanoate β-oxidation to 13CO2 was measured over 12 h on the pre- and post-MCT metabolic study days.ResultsOn the post-MCT metabolic study day, plasma ketones (β-hydroxybutyrate plus acetoacetate) peaked at 476 μM, with a mean value throughout the study day of 290 μM. Post-MCT, 13C-trioctanoate β-oxidation was significantly lower 1 to 8 h later but higher 10 to 12 h later. MCT supplementation did not significantly alter 13C-D-β-hydroxybutyrate oxidation.ConclusionsThis MCT supplementation protocol was mildly and safely ketogenic and had no side effects in healthy humans on their regular diet. This degree of ketonemia is estimated to contribute up to 8% to 9% of brain energy metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 29, Issue 4, April 2013, Pages 635-640
نویسندگان
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