کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6091923 | 1209772 | 2016 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma
ترجمه فارسی عنوان
نصب فشار در محیط میکروتیک: مایعات، جامدات و سلول ها در آدنوکارسینومای داکتل پانکراس
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کلمات کلیدی
ECMPDAGAGIFPPancreatic ductal adenocarcinoma - آدنوکارسینوم پانکراس داکتالHyaluronic acid - اسید هیالورونیکDrug delivery - تحویل(رهایش) داروInterstitial pressure - فشار بینابینیInterstitial fluid pressure - فشار مایع بینابینیExtracellular matrix - ماتریکس خارج سلولیHyaluronan - هیالورونانpolyethylene glycol - پلی اتیلن گلیکولPEG - پلیاتیلن گلیکول Glycosaminoglycan - گلیکوزآمینوگلیکان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
چکیده انگلیسی
The microenvironment influences the pathogenesis of solid tumors and plays an outsized role in some. Our understanding of the stromal response to cancers, particularly pancreatic ductal adenocarcinoma, has evolved from that of host defense to tumor offense. We know that most, although not all, of the factors and processes in the microenvironment support tumor epithelial cells. This reappraisal of the roles of stromal elements has also revealed potential vulnerabilities and therapeutic opportunities to exploit. The high concentration in the stroma of the glycosaminoglycan hyaluronan, together with the large gel-fluid phase and pressures it generates, were recently identified as primary sources of treatment resistance in pancreas cancer. Whereas the relatively minor role of free interstitial fluid in the fluid mechanics and perfusion of tumors has been long appreciated, the less mobile, gel-fluid phase has been largely ignored for historical and technical reasons. The inability of classic methods of fluid pressure measurement to capture the gel-fluid phase, together with a dependence on xenograft and allograft systems that inaccurately model tumor vascular biology, has led to an undue emphasis on the role of free fluid in impeding perfusion and drug delivery and an almost complete oversight of the predominant role of the gel-fluid phase. We propose that a hyaluronan-rich, relatively immobile gel-fluid phase induces vascular collapse and hypoperfusion as a primary mechanism of treatment resistance in pancreas cancers. Similar properties may be operant in other solid tumors as well, so revisiting and characterizing fluid mechanics with modern techniques in other autochthonous cancers may be warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 150, Issue 7, June 2016, Pages 1545-1557.e2
Journal: Gastroenterology - Volume 150, Issue 7, June 2016, Pages 1545-1557.e2
نویسندگان
Christopher C. DuFort, Kathleen E. DelGiorno, Sunil R. Hingorani,