کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6093657 | 1209791 | 2015 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in Diagnosis and Management of Celiac Disease
ترجمه فارسی عنوان
پیشرفت در تشخیص و درمان بیماری سلیاک
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کلمات کلیدی
IELEATLRCDEMATTGDGPGFDVillous atrophy - آتروفی ویولوزEnteropathy - انتروپاتیEnteritis - انتیتRefractory celiac disease - بیماری سلیاک یخ زدهTissue transglutaminase - ترانس گلوتامیناز بافتیAutoimmune - خودایمنیDiet - رژیم غذاییGluten-free diet - رژیم غذایی فاقد گلوتنSerology - سرمشناسی یا سرولوژیCereal - غلاتMalabsorption - فروپاشیIntraepithelial lymphocyte - لنفوسیت داخل اپیتلیالLymphoma - لنفومEnteropathy-associated T-cell lymphoma - لنفوم سلول T مرتبط با انتروپاتیRefractory - محصولات دیرگداز، دیرگدازdeamidated gliadin peptide - پپتید گلیادین deamidatedNutritional deficiency - کمبود تغذیه ایGluten - گلوتنWheat - گندم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
چکیده انگلیسی
Celiac disease is an autoimmune disorder that is induced by dietary gluten in genetically predisposed individuals. It has a prevalence of approximately 1% in many populations worldwide. New diagnoses have increased substantially, owing to increased awareness, better diagnostic tools, and probable real increases in incidence. The breadth of recognized clinical presentations continues to expand, making the disorder highly relevant to all physicians. Newer diagnostic tools, including serologic tests for antibodies against tissue transglutaminase and deamidated gliadin peptide, greatly facilitate diagnosis. Tests for celiac-permissive HLA-DQ2 and HLA-DQ8 molecules are useful in defined clinical situations. Celiac disease is diagnosed by histopathologic examination of duodenal biopsy specimens. However, according to recent controversial guidelines, a diagnosis can be made without a biopsy in certain circumstances, especially in children. Symptoms, mortality, and risk for malignancy each can be reduced by adherence to a gluten-free diet. This treatment is a challenge, however, because the diet is expensive, socially isolating, and not always effective in controlling symptoms or intestinal damage. Hence, there is increasing interest in developing nondietary therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 148, Issue 6, May 2015, Pages 1175-1186
Journal: Gastroenterology - Volume 148, Issue 6, May 2015, Pages 1175-1186
نویسندگان
Ciarán P. Kelly, Julio C. Bai, Edwin Liu, Daniel A. Leffler,